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-> ´´My´´ Dissertation – Tables, Figures and Graphics
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– 10/14/2023 – I am available to receive partnership proposals with this Blog: https://science1984.wordpress.com/2023/10/14/i-am-available-to-receive-partnership-proposals-with-this-blog-estou-disponivel-para-receber-propostas-de-parceria-com-este-blog-thisblogpost-name-indeterminedtime-time-probabilities-countries/
—> Very Important Phrases from Bill Gates, Jeff Bezos, Elon Musk and Steve Jobs – YouTube Videos: https://science1984.wordpress.com/2023/10/21/very-important-phrases-from-bill-gates-jeff-bezos-elon-musk-and-steve-jobs-youtube-videos-frases-muito-importantes-reading-leitura-click-this-post-este-post-probability-pos/
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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.
The influence of physical activity in the progression of experimental lung cancer in mice
Renato Batista Paceli 1, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
Impact_Fator-wise_Top100Science_Journals
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
https://pubmed.ncbi.nlm.nih.gov/22683274/
Abstract
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
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I am graduated in Biomedicine at Federal University of Triangulo Mineiro (Uberaba – 2003-2007), I have a Master Degree in lung cancer research in mice at Faculty of Medicine of Sao Jose do Rio Preto (2008-2012) and nowadays I work as inspector of students since 2012 in Sao Jose do Rio Preto. Maybe I can try to do a doctorate and PhD to work as professor, scientist and/or researcher in Brazil or abroad. As you know, the human interdependence is essential for a country progress in many aspects. In my dissertation I did very interesting, important, innovative and detailed graphics about variations of all mice weights (Control Group, Study Group 1 and Study Group 2) of different ages during all experimental time and I did comparisons between them to a better and detailed analysis. It was a very innovative and important research as well my monograph (Chagas disease research -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi). There were not statistical difference significantly among them, but the discussion of this fact is very important to the Scientific Community, conforming an article published in Nature (It’s time to talk about ditching statistical significance – Looking beyond a much used and abused measure would make science harder, but better. 20 MARCH 2019). There are posts in my blog about this very important subject for Science. Discovering how the initial stages of certain diseases work, such as fatal diseases, is of huge importance for Science, of course. There are several biological factors connected in the human body that acting in a very complex form. Therefore, it is of great necessity to carry out new scientific researches much more detailed and modern, with high degree of precision, even if there is no significant statistical difference between certain factors. New Scientific Discoveries are essential for the world progress always. As you know, we need to have more efficient vaccines and drugs, so it is very important to do more detailed and efficient researches in mice and humans, of course. There are very important stages of development of vaccines and drugs, for sure. So, I would like so much you share this blog I did. I do not earn money from the blog. I never earned any money from blogs I did, nor my social networks nor my e-mails accounts. I never earned any money using Internet. (02/19/2021)
Compreender como funciona os estágios iniciais de uma determinada doença, tal como uma doença fatal, é de enorme importância para a Ciência, com toda certeza. Há vários fatores biológicos interligados no corpo humano que atuam de forma muito complexa. Portanto, é de grande necessidade a realização de pesquisas científicas muito mais minuciosas envolvendo alta tecnologia, com alto grau de precisão, mesmo que NÃO haja diferença estatística significativa entre determinados fatores analisados em gráficos, por exemplo. (02/19/2021)
This blog content is very good with very high quality! There are a very big amount of excellent information in this blog like human health, scientific researches in humans and animal models for human diseases like cardiovascular diseases, for example. The diffusion of knowledge is essential for a country progress always!! Article of my dissertation: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. The graphics I did about the variations of all mice weights of different ages during all experimental time aren´t in the scientific article related to my dissertation nor in my dissertation as well as details about time of exercise and rest of the animals. These data can be an excellent reference for many types of researches like genetic engineering. The age of the mouse and the human being with the genetics influence in certain ways in pathophysiology in the humans and mice. So, mice researches are very important for the society as well as researches with humans, for sure. (02/19/2021)
I was invited by Internet through direct messages to participate in 72 very important science events in 31 cities in less than 2 years (Auckland, Melbourne, Toronto, Edinburgh, Madrid, Suzhou, Stanbul, Miami, Singapore, Kuala Lumpur, Abu Dhabi, San Diego, Bangkok, Dublin, Sao Paulo, Dubai, Boston, Berlin, Stockholm, Prague, Valencia, Osaka, Amsterdam, Helsinki, Paris, Tokyo, Vienna, Rome, Zurich, London and Frankfurt) because I participated of very important researches. Images about it are in this blog, of course. Many people worldwide visited it and liked my blog, such as renowned professors, scientists and researchers!! So, this blog sharing is very important to the world society!! More people worldwide need to know about it!! (02/19/2021)
Many laboratories have been researching mice for a long time, even resulting in excellent prizes for researchers such as the Nobel Prize. For example, the Jackson Laboratory. The world needs to have more very good and efficient ideas and scientific discoveries for human live longer faster more and more.
Many people think they have made mistakes but in fact they have not made mistakes. Many people think they did the right thing but they did not. The important thing is to reflect on this in order to better know the origin of your thoughts and your thoughts, acting accordingly in the best way for the good of you and other people.
Muitos acham que erraram mas na verdade não erraram. Muitos acham que acertaram mas não acertaram. O importante é refletir sobre isso para conhecer melhor a origem de seus pensamentos e seus pensamentos em si, agindo consequentemente da melhor forma para o bem de si e da(s) outra(s) pessoa(s).
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My YouTube Channel -> https://www.youtube.com/channel/UC9gsWVbGYWO04iYO2TMrP8Q
Link about my monograph: Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi:
https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/
https://science1984.wordpress.com/2019/05/08/21809/
-Links about animal model for human diseases like cardiovascular diseases: https://science1984.wordpress.com/2020/04/29/33426/
– Links related with ´´my´´ dissertation: https://science1984.wordpress.com/2019/11/28/links-of-my-dissertation-the-influence-of-physical-activity-in-the-progression-of-experimental-lung-cancer-in-mice-and-monograph-induction-of-benzonidazole-resistance-in-human-isolates-of-trypanoso/
https://science1984.wordpress.com/2019/05/08/21809/
https://www.youtube.com/watch?v=mWWDMV2W7QM Gratitude: I was invited direclty throught direct messages to participate in 55 very important science events in 25 cities of different countries in less than 1 year. Informations about it are in ´´my´´ blog.https://www.youtube.com/embed/mWWDMV2W7QM?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent
Science events and researches are essential for the world progress in all aspects. The world is interdependent, of course. Unfortunately there´re fatal diseases without very efficient drugs and total prevention methods like vaccination. The scientific work can be very hard but can be of relevant value to the people. Therefore, new very important scientific discoveries are fundamental for human life urgently in the world, of course.
It´s very important professors, scientists, students, researchers and other people worldwide know about ´´my´´ dissertation made at Faculty of Medicine of Sao Jose do Rio Preto because it was a very innovative and important research as well as ´´my´´ monograph. They are related to very relevant subjects.
The data like very detailed, interesting and important graphics I made about variations of weights in all mice of different ages (Control Group -> treated with urethane and without physical activity and Study Groups – Aerobic Group -> treated with urethane and subjected to aerobic swimming free exercise – Anaerobic Group –> treated with urethane and subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight) during all experimental time [My dissertation -> Lung cancer research in mice – Article: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81] are very important for the world scientific community.
These graphics I did related to my dissertation aren´t in the article nor in ´´my´´ dissertation as well as details about time of exercise and rest of the animals. They can be an excellent reference for many types of researches in mice and humans, like in the field of genetic engineering. The discussion of certain facts in science envolving stastistics is fundamental to the scientific community, for example, the analysis and interpretation of very important, innovative and interesting graphics with no statistical difference between them can have a big value to the researches and to the future researches. So, the quality and efficiency of researches can increase so much in a little time, increasing the possiblities of excellent references and new scientific discoveries. The facts veracity and the disclosure of them are essential for the scientific community, of course. Links about this subject:
The age of the human, of the animal like mouse and the genetics influence in certain ways in the pathophysiology and in other aspects in the humans and mice. This subject is not easy to understand, of course. So, mice researches are essential for the world society as well as human researches. More information about it are in these links:
https://science1984.wordpress.com/2020/03/27/32357/
Very important observations:
- Cancer is very related to the weight loss of the patient. Weight loss of the patient is very associated with cancer – The syndrome of Anorexia-Cachexia (SAC) is a frequent complication in patients with advanced malignant neoplasia.
- Age, weight and genetics of the person are very important factors that influence cancer in a determined ways.
- The genetics of the mouse is very similar to that of the human.
- Maintaining proper body weight is one of the main ways to prevent cancer of a person.
- Animal testing has a very high importance to world society.
- The mouse is the main animal model used as the basis for research on diseases that affect humans.
- Weight lifting (bodybuilder) is a very good example of anaerobic physical activity in humans.
In ´´my´´ dissertation the progression of lung cancer was lower in the group of mice that practiced anaerobic physical activity. It would be very important, innovative and interesting to do researches in mice and humans testing a substance or substances and analyzing biochemical, pathological, pharmacological and physiological factors like weights in all experimental time and the influence of age and genetics within the group itself and in the other groups in the inhibition and/or progression of a determined disease like cancer. In this context, it´s very important to seek new methodologies for the treatment, prevention and early detection of cancer and/or other diseases, such as vaccines and other very modern and efficient technologies. It is clear that the correct and accurate study of cancer (as an example, the conduct of scientific researches) and certain diseases, is very complicated to be performed because they´re very complex diseases that are difficult to understand.
Note about ´´my´´ dissertartion: during anaerobic exercise it was necessary to briefly hold the tail of the mice for better physical performance and better adaptation to the submitted environment. In this same type of exercise, there were times when the mice could not exercise and sank, causing manual manipulation again. The physical wear of the animals was very intense.
It´s very important to consider the significance of variants of weight, age and genetics em relation to cancer. It is not easy understand it, of course. Therefore, more researches about it are very necessary in the world.
I hope that researchers, teachers, students, scientists and other people linked to scientific researches worldwide use the graphics I made about the variations of all mice weights during all experimental time of ´´my´´ dissertation as an example, model or reference for conducting future scientific researches as well as other data from ´´my´´ monograph and dissertation, leading to a very beneficial innovation in the researches methodologies bringing very relevant results to the world society, significantly increasing the human life time more and more.https://www.businessinsider.com/mars-landing-nasa-perseverance-rover-touches-down-in-jezero-crater-2021-2?utm_campaign=sf-bi-ti&utm_source=facebook.com&utm_medium=social&fbclid=IwAR3gDM2RsrO9tWUtFGW0CD9jSCudJUj3j3wF-yBaD6KMjuLuc-EH8Fei47I
Rodrigo Nunes Cal’s research works
| Rodrigo Nunes Cal’s research worksRodrigo Nunes Cal’s 1 research works with 12 citations and 137 reads, including: The influence of physical activ… |
I hope collaborate significantly with these information in the world scientific progress always!
The world needs to improve so much in the best ways.
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http://www.science1984.wordpress.com
Turning Drug Delivery Inside Out How spherical nucleic acid (SNA) technology may solve the challenge of delivering oligonucleotides into cells & ´´Chaos theory is a branch of mathematics focusing on the study of chaos—states of dynamical systems whose apparently-random states of disorder and irregularities are often governed by deterministic laws that are highly sensitive to initial conditions.[1][2]´´ @ VERY IMPORTANT SOCIAL NETWORKS, WEBSITES, LINKS AND IMAGES OF THE WORLD
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