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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli ¹, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury

• PMID: 22683274
• DOI: 10.1016/j.prp.2012.04.006

Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

Copyright © 2012 Elsevier GmbH. All rights reserved.

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MAIS INFORMAÇÕES

Sobre

Founded in 1636, Utrecht University is one of the largest research universities of Europe. We invest in passionate and internationally-oriented top students & top researchers, who we train as leaders of the future.

 

Informações gerais

Utrecht University has:
– 7 faculties: Humanities; Law, Economics and Governance; Geosciences; Social and Behavioural Sciences; Science; Medicine / University Medical Center Utrecht (UMC Utrecht) and Veterinary Medicine.
– 30,152 students.
– 6,500 staff members (excluding Faculty of Medicine).
– approx. 125,000 alumni.

 

Prêmios

The Shanghai Ranking ranks Utrecht University as 1st in the Netherlands and 47th in the world. The Best Global Universities Ranking ranks the University als 1st in the Netherlands and 12th in Europe. The Times Higher Education Ranking places the university at number 68. The university has also been ranked as 36th worldwide by the Taiwan Ranking, published by the Higher Education Evaluation & Accreditation Council.

 

Produtos

– 58 Bachelor’s programmes, 10 of which are English-taught.
– 146 Master’s programmes, 97 of which are English-taught.
>> The widest range of English-taught Master’s programmes in the Netherlands.

 

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To visit Utrecht Science Park (or: ‘the Uithof’) from Utrecht Central Station, take the bus and get off at the bus stop “Heidelberglaan”. To visit our locations in the city centre by bus, we recommend you to visit: https://9292.nl/en.

 

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2011

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1999

• Nobel Prize for Gerard ’t Hooft

1961

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