A Facebook message like this for me is very important because it reflects how this blog is viewed by person or people who visited it: ´´Okay sir no problem .i want say your work is remarkable and i am really impressed..ive sae ur blog and content…this is really innovative and next level…thank you´´ @ Uma mensagem do Facebook como essa para mim é muito importante porque reflete como esse blog é visto pela(s) pessoa(s) que o acessou(aram) ´´Ok, senhor, não há problema. Quero dizer que seu trabalho é notável e estou realmente impressionado … eu vi seu blog e conteúdo … isso é realmente inovador e é o próximo nível … obrigado´´ @ Other Facebook message for me about this blog: ´´Rodrigo Cal I did visit your blog and it’s packed with things. Will come back when I have more time! Keep up the great work and effort!´´@ Outra mensagem do Facebook sobre este blog pra mim: ´´Rodrigo Cal ´´Eu visitei o seu blog e está cheio de coisas. Voltará quando tiver mais tempo! Mantenha o excelente trabalho e esforço!´´ ´´Facebook is an American online social media and social networking service based in Menlo Park, California and a flagship service of the namesake company Facebook, Inc. It was founded by Mark Zuckerberg, along with fellow Harvard College students and roommates Eduardo Saverin, Andrew McCollum, Dustin Moskovitz and Chris Hughes. The founders initially limited Facebook membership to Harvard students. After registering, users can create a profile revealing information about themselves. They can post text, photos and multimedia which is shared with any other users that have agreed to be their “friend”, or, with a different privacy setting, with any reader. Facebook claimed that it had more than 2.3 billion monthly active users as of December 2018.´´ https://en.wikipedia.org/wiki/Facebook,_Inc. @ ´´Google LLC is an American multinational technology company that specializes in Internet-related services and products, which include online advertising technologies, a search engine, cloud computing, software, and hardware. It is considered one of the Big Four technology companies alongside Amazon, Apple, and Microsoft. Google was founded in September 1998 by Larry Page and Sergey Brin while they were Ph.D. students at Stanford University in California. Together they own about 14 percent of its shares and control 56 percent of the stockholder voting power through supervoting stock. An initial public offering (IPO) took place on August 19, 2004, and Google moved to its headquarters in Mountain View, California, nicknamed the Googleplex. In August 2015, Google announced plans to reorganize its various interests as a conglomerate called Alphabet Inc. Google is Alphabet’s leading subsidiary and will continue to be the umbrella company for Alphabet’s Internet interests. Sundar Pichai was appointed CEO of Google, replacing Larry Page who became the CEO of Alphabet. The company’s rapid growth since incorporation has triggered a chain of products, acquisitions, and partnerships beyond Google’s core search engine (Google Search). Google.com is the most visited website in the world. Several other Google services also figure in the top 100 most visited websites, including YouTube and Blogger. Google was the most valuable brand in the world in 2017 (surpassed by Amazon), but has received significant criticism involving issues such as privacy concerns, tax avoidance, antitrust, censorship, and search neutrality.´´ SOURCE — IDEAS – MONOGRAPH — DISSERTATION – VERY DETAILED GRAPHICS – SCIENCE EVENTS – EVENTO(S) CIENTÍFICO(S) – DIRECT INVITATIONS – SPEAKER – DELEGATE – POSTERS – GRÁFICO(S) MUITO BEM DETALHADO(S) – POSTER – REFERENCE – REFERÊNCIA(S) – REFERENCES – WORDS — NAMES — NOME(S) – PHRASES — MESSAGES – MENSAGEM(NS) – EFFICIENT SEARCHES — GRANDE TECNOLOGIA(S) – SOURCES — LINKS — WEBSITES — VERY HIGH TECHNOLOGIES — DISCUSSION – HUMAN AND EXPERIMENTAL PHYSIOLOGY – HUMAN AND EXPERIMENTAL PATHOLOGY – GENETICS – DISEASES – DISEASE – 100 – NOME(S) – DOENÇA(S) -@ T I M E — TEMPO – INÍCIO – INITIAL PROCESS OF THE DISEASE — 100 DISEASES – NO TIME – NO(S) TIME(S) – INTERPTRETATIONS – INTERPRETAÇÃO(ÕES) – MICE RESEARCHES – HUMAN RESEARCHES – INVESTMENTS – LABORATORIES – LABORATÓRIO(S) – INVESTIMENTO(S) – DETAILED ANALYSIS – ANÁLISE(S) DETALHADA(S) — RESEARCH GROUPS – STATISTICAL DIFFERENCES – GRUPOS EXPERIMENTAIS – A G E S @ TIME – A G E – INFLUENCE – EXPERIMENTAL TIME – TEMPO EXPERIMENTAL – GENE – GENE(S) – DNA @ RNA – CELL @ NO GENE – INFLUÊNCIA(S) — MICE – MOUSE & I D A D E (S) -@- HUMANS – HUMAN – IDADE – IDADES – TESTS RESULTS – WEBSITE – LINK(S) – TEST – TESTE(S) – BLOGS – BLOG(S) – INTERNET – ANIMAL TESTING – – RESULTADO(S) – LONGEVITY – LONGEVIDADE – ARTICLES – SCIENCE MAGAZINES – REVISTA(S) CIENTÍFICA(S) – ARTIGO(S) CIENTÍFICO(S) – MONEY – DINHEIRO – WORK – TRABALHO – PERSON – PEOPLE – PESSOA(S) – SCIENTIFIC COMPROVATIONS – COMPROVAÇÃO(ÕES) CIENTÍFICA(S) — JOURNALS – IMPACT FACTORS – IMPORTANCE – IMPORTÂNCIA CIENTÍFICA – – FATORE(S) DE IMPACTO — PUBLICATIONS – PUBLICAÇÃO(ÕES) – CITATIONS – – CITAÇÃO(ÕES) – – PRIZES – PRÊMIO(S) – – RANKING @ https://en.wikipedia.org/wiki/Google @ https://en.wikipedia.org/wiki/Facebook @ Study identifies 68 genes associated with risk of severe COVID-19 – A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials. By Victoria Rees (Drug Target Review) 26 June 2020 @ DISCOVERING HOW THE INITIAL STAGES OF A CERTAIN DISEASE WORKS, SUCH AS A FATAL DISEASE, IS OF HUGE IMPORTANCE FOR SCIENCE, FOR SURE. THERE ARE SEVERAL BIOLOGICAL FACTORS CONNECTED IN THE HUMAN BODY THAT ACTING IN A VERY COMPLEX FORM. THEREFORE, IT IS OF GREAT NECESSITY TO CARRY OUT NEW SCIENTIFIC RESEARCHES MUCH MORE DETAILED AND MODERN, WITH A HIGH DEGREE OF PRECISION, EVEN IF THERE IS NO SIGNIFICANT STATISTICAL DIFFERENCE BETWEEN CERTAIN FACTORS. @ VERY IMPORTANT TWITTER IMAGES THAT SHOWS THE RELATION AMONG DEATHS, SEX, AGE GROUP AND TIME IN THE UNITED STATES. IT´S RELATED TO COVID-19, PNEUMONIA, AND INFLUENZA. @ ANOTHER TWITTER IMAGE INDICATES THE ETHICAL CHALLENGES CREATED BY CRISPR TECHNOLOGY @ FACEBOOK IMAGES ABOUT MESSAGES I HAVE RECEIVED RELATED TO THIS BLOG
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DISCOVERING HOW THE INITIAL STAGES OF A CERTAIN DISEASE WORKS, SUCH AS A FATAL DISEASE, IS OF HUGE IMPORTANCE FOR SCIENCE, FOR SURE. THERE ARE SEVERAL BIOLOGICAL FACTORS CONNECTED IN THE HUMAN BODY THAT ACT IN A VERY COMPLEX FORM. THEREFORE, IT IS OF GREAT NECESSITY TO CARRY OUT NEW SCIENTIFIC RESEARCHES MUCH MORE DETAILED AND MODERN, WITH A HIGH DEGREE OF PRECISION, EVEN IF THERE IS NO SIGNIFICANT STATISTICAL DIFFERENCE BETWEEN CERTAIN FACTORS.
DESCOBRIR COMO FUNCIONA OS ESTÁGIOS INICIAIS DE UMA DETERMINADA DOENÇA, TAL COMO UMA DOENÇA FATAL, É DE ENORME IMPORTÂNCIA PARA A CIÊNCIA, COM CERTEZA. HÁ VÁRIOS FATORES BIOLÓGICOS INTERLIGADOS NO CORPO HUMANO QUE ATUAM DE FORMA MUITO COMPLEXA. PORTANTO, É DE GRANDE NECESSIDADE A REALIZAÇÃO DE NOVAS PESQUISAS CIENTÍFICAS MUITO MAIS MINUCIOSAS E MODERNAS, COM ALTO GRAU DE PRECISÃO, MESMO QUE NÃO HAJA DIFERENÇA ESTATÍSTICA SIGNIFICATIVA ENTRE DETERMINADOS FATORES.
Study identifies 68 genes associated with risk of severe COVID-19
A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials.
A unique artificial intelligence (AI) platform has revealed 68 genes associated with the risk of developing severe COVID-19, following the analysis of the genomes of 929 patients from the UK Biobank who had a severe response to SARS-CoV-2.
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The researchers at PrecisionLife say the insights may help to identify patients who are at greatest risk of developing the most severe forms of COVID-19. They can inform the development of biomarker driven tests, targeted shielding and new therapeutic strategies, with the aim of identifying high-risk people, reducing disease burden and improving survival rates, say the scientists.
According to the team, established Genome Wide Association Studies (GWAS) approaches have been limited by the heterogenous nature of COVID-19, making it difficult to clearly explain the wide range of symptoms and impacts of predisposing comorbidities associated with the disease. However, this study has overcome this barrier by evaluating combinations of genetic features, which is not possible with existing GWAS approaches.
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Using a combinatorial (high-order epistasis) analysis approach, the researchers identified 68 protein-coding genes that were highly associated with severe COVID-19, nine of which have been previously linked to differential response to SARS-CoV-2. These 68 genes include several druggable protein targets and pathways, nine of which are targeted by drugs that have reached at least Phase I clinical trials.
As more genomic records and additional medical data become available in the UK Biobank and other data sources, PrecisionLife says it will extend its analyses to fully ascertain the differences between severe and mild COVID-19 cases and provide an additional layer of validation to the results from this study.
Dr Steve Gardner, Chief Executive Officer of PrecisionLife said: “We know that systemic remodelling, leaky vasculature and micro-clotting can cause severe issues in COVID-19 patients in lungs as well as other organs. We are encouraged that several of the genes identified relate to lipid programming, beta-catenin and protein kinase C signalling whose processes converge in a central pathway involved in plasma membrane repair, clotting and wound healing. This pathway is largely driven by calcium ion activation, which is a known serum biomarker associated with severe COVID-19 and acute respiratory distress syndrome (ARDS). We intend to perform further analyses to investigate this hypothesis. We are also seeking to further validate 12 genes associated with dysfunctional immune response that are the first hint at a potential genetic signature for enhanced risk of flipping into a severe disease state.”
PrecisionLife emphasises that one limitation of the UK Biobank dataset is that the ethnicity distribution of the participants is heavily skewed to white British participants and it has consequently not been possible to fully investigate additional risk factors in BAME patients. It is actively seeking to investigate severe COVID-19 risk factors in other global datasets with more ethnically diverse populations.
The results of this study have been uploaded to the pre-publication site, medRxiv.